Taking Estrogen by mouth is not natural. When you are producing your own Estrogen it is released into your bloodstream. When Estrogen is taken by mouth, it must be processed by your liver. When Estrogen is taken via a patch, pellet, or transdermal cream, it is then able to exert it’s positive effects on all the tissues of your body. Medical studies report that Estrogen is brain protective, heart protective, and bone protective. Estrogen also has many positive effects on your mood, skin, hair, and bladder.