These study notes are the result of women who are frightened because they were required to have additional mammograms, ultrasounds, MRIs of their breasts. Some were even required to have a needle excision localized biopsy. Often, I was the only doctor with whom these women could entrust their angst at 6 pm on a Friday night. The medical environment is full of fear which is reflected in the voices of those women. To date, not one case of breast cancer has been found after prescribing bioidentical hormone replacement therapy for nearly two decades.

This angst led me to reexamine the medical data to see – Does Estrogen Cause Breast Cancer???


Progesterone (real Progesterone, not Progestins and Progestins found in Provera and Oral Contraceptives)
B12* in the form of Methylcobalamin (not Cyanocobalamin or Hydroxocobalamin) administered sublingually or by injection converts Estrogen to 2-Methoxyestrogen
Iodine** stimulates the metabolism of Estradiol and Estrone into Estriol and forms Iodolipids (fats combine with Iodine) thus killing many types of Breast Cancer
2 Methoxyestrogen
Flax Oil and lignans (fiber) enhances conversion of Estrogen to 2-Hydroxyestrogen
Indole 3 Carbinol (I3C) enhances conversion of Estrogen to 2-Hydroxyestrogen
Increased 2/16 ratio of 2-Hydroxyestrogen to 16-Hydroxyestrogen
Vitamin D (presently known to turn off 63 cell lines of Cancer)
DHEA (Dehydroepiandosterone) (decreases G6PD-Glucose 6 Phosphate Dehydrogenase which feeds anerobic energy to cancer cells)


There are literally hundreds of types of Estrogen, some good, some really good, some carcinogenic. The most carcinogenic are the Xenoestrogens that we get from the environment and our food supply. Girls as young as 8 are getting their first period from all the bad Estrogen they are eating.

There are 3 major types of Estrogen:

Estrone or E1 which is in our fat cells – so possessing too much fat predisposes one to Breast Cancer. However, E1 can convert to E3 with minor lifestyle modifications

Estradiol or E2 which is the predominant Estrogen we make in our 20s, this is the strongest, and notice I did not say the worst – converting to 16 Hydroxyestrogen is the worst

Estriol or E3 which is the Estrogen we make during pregnancy and is the weakest Estrogen. This weak Estrogen is known to be anticarcinogenic. Hence, this is the reason that
women who have multiple pregnancies have a lower incidence of Breast Cancer. Note that we have been having fewer and fewer children.


Countless Xenoestrogenic (fake) Estrogens in our environment (read You are Full of Estrogen Even If You Are Not Taking Estrogen on this site)
Stress (COMT cannot methylate your Estrogen if it is methylating your increased Adrenaline)
Toxic food, toxic hunger, cravings which are not hunger
Not knowing how many pounds of fat you are and being over fat as a result, it is not about losing weight, it is about losing fat — slowly, it is toxic
Insufficient Progesterone, Estriol, B12, Iodine, Testosterone, DHEA, Vitamin D, Melatonin
Estrogen taken by mouth
Longtime use of oral contraceptives
Deficiency of Progesterone, Estriol, Testosterone, Melatonin, DHEA, Iodine, Vitamin D, B 12, Indole 3 Carbinol
Synthetic Estrogen (it is too strong)
Alcohol in excess
Protein and Dairy (read The China Study)
Too little exercise (oxygen kills cancer cells)
Too much sugar (sugar helps cancer grow)
Acidic foods (the American diet with the present pyramid is acidic and a whole food based diet rich in volume and nutrients is alkaline)***

Study Notes:

Estrogen taken by mouth increases certain cancers, increases risk of blood clots, and increases cholesterol

Synthetic Progestins increase incidence of Breast Cancer and CONSTRICT CORONARY ARTERIES. RFM comments, why, why are birth control pills which contain this stuff routinely prescribed

Women who make the most Estriol during pregnancy produce the most Estriol throughout their menstrual cycle years

Estradiol converts to Estrone and then Estriol with the addition of Iodine (which is quite low in our present diets)

Cure for Fibrocystic Breast Disease is to increase Estriol with Iodine or Iodide

Iodine protects against Breast Cancer via forming Iodolipids which are fats that combine with Iodine in the breast and kills many types of Breast Cancer

2/16 ratio if low = increased Cancer, if high = increased Osteoporosis

Increased 4-Hydroxyestrogen = increased Cancer —- lower via decreasing Equine/Horse Estrogen prescription

2-Methoxyestradiol is the goal, methylate via COMT Catechol O Methyltransferase; i.e., B12, Methylfolate the active folic acid, and SAMe

COMT also methylates Adrenaline, if busy methlylating Adrenaline, it can’t methylate Estrogen, SO decrease stress

For Men – Testosterone converts to Estradiol and DHT Dihydrotestosterone

Increased DHT is Procarcinogenic but DHT can convert to Androstenediol which is anticarcinogenic

Interestingly, too much Proscar, Propecia, Zinc, GLA, and Saw Palmetto can cause too much of a decrease in DHT which is not the goal, 24 hour urine test is best

Too much inhibition of DHT is carcinogenic

Thyroid – Rx of Thyroid without Iodine (not Iodide) increases by 2X Cancer of the Thyroid risk factor

* since 2 Methoxyestradiol is the goal, one methylates via the pathway COMT (Catechol O Methyltransferase) with Methylcobalamin (B12) Methylfolate (active Folic Acid) or SAMe. Note that
COMT also methylates adrenaline, so if busy methlylating adrenaline because you are stressed to the breaking point, it cannot methylate Estrogen. DECREASE STRESSORS TO PREVENT
**The CURE for both fibrocystic breast disease as well as increasing Estriol levels is sufficient Iodine or Iodide – work with a physician who is knowledgeable in nutritional biochemistry
***Cancer grows in an acidic environment